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检测了新疆四大片鼠疫自然疫源地内不同宿主、不同年代的109株鼠疫菌的质粒，发现除一株1970年分离自玛纳斯灰旱獭的菌株自然缺失6Mdal质粒、只携带45和65Mdal二种质粒、并伴随鼠疫杆菌素（Pstl）表型丧失外，其余所有的菌株均携带三种质粒。其中80％的菌携带6、45和65Mdal质粒。三种质粒中，6Mdal质粒比较稳定，无明显变化。编码钙依赖和F1抗原的二种质粒分子量变化较大，前者可增大至49和56Mdal，后者可增大至74和91Mdal。根据鼠疫菌所含三种质粒分子量不同，将新疆鼠疫菌质粒图谱分为Ⅰ～Ⅴ个型。北天山灰旱獭-长尾黄鼠鼠疫疫源地有Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ五个类型，南天山灰旱獭鼠疫疫源地有Ⅰ、Ⅴ两种类型，帕米尔高原-阿赖山红旱獭和昆仑山喜玛拉雅旱獭鼠疫疫源地只有Ⅰ型。由于鼠疫菌的质粒图谱在各疫源地内的分布不同，可将其作为新疆鼠疫疫源地划分及鼠疫菌分型的重要指标。
The plasmids of 109 Y. pestis isolates from different hosts and ages in the natural foci of plague in Xinjiang were detected and found that only one strain of Mandellas marmian that was isolated in 1970 was naturally deficient in the 6Mdal plasmid and only carried 45 and 65Mdal Plasmids, with the loss of the phenotype of the Pstl, all the remaining strains carried three plasmids. Eighty percent of the bacteria carry 6,45 and 65 MDal plasmids. Of the three plasmids, the 6Mdal plasmid was stable with no significant change. The two plasmids, which encode calcium-dependent and F1 antigens, varied considerably in size, with the former increasing to 49 and 56 MDal, which increased to 74 and 91 MDal. According to the different molecular weight of the three plasmids contained in Y. pestis, the plasmid map of Y. pestis in Xinjiang is divided into Ⅰ ~ Ⅴ type. There are five types Ⅰ, Ⅱ, Ⅲ, Ⅳ and Ⅴ of plague fossils in the northern Tianshan Mountains. There are two types Ⅰ and Ⅴ of plague flies in the southern Tianshan Mountains. Pamirs - Only the type I is found in the red marmot and the marmot of the Himalayan Kunlun Mountains. Due to the different distribution of plasmid maps of Y. pestis in each of the foci, it can be used as an important index to classify plague origin and type distribution of Y. pestis in Xinjiang.