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目的探讨病毒性心肌炎(VM)患儿血清心肌钙蛋白I(cTnI)检测阳性与时间的关系。方法临床诊断为急性VM患儿21例,分别于入院后不同时间静脉采血,动态检测血清cTnI,并与35例正常对照组比较。结果正常对照组血清cTnI均阴性;VM患儿刚入院时阳性6例(28.6%),至入院后6、12、18、24、48、72 h,10~14 d分别为7例(33.3%)、8例(38.1%)、9例(42.9%)、9例(42.9%)、13例(61.9%)、4例(19%)。入院后48、72 h cTnI累计阳性率分别较刚入院时和入院后10~14 d有显著性差异(P均<0.05)。结论对临床上拟诊VM发病不久患儿,通过不同时间段反复多次采血,能提高cTnI检出阳性率。
Objective To investigate the relationship between serum cTnI and time in children with viral myocarditis (VM). Methods Twenty-one patients were diagnosed as acute VM. Serum cTnI was detected at different time points after admission, and compared with 35 normal controls. Results The serum levels of cTnI in the normal control group were all negative. The positive rate of cTnI in the normal control group was 6 cases (28.6%) at admission, 6,12,18,24,48,72 h after admission, 7 cases (33.3% ), 8 cases (38.1%), 9 cases (42.9%), 9 cases (42.9%), 13 cases (61.9%) and 4 cases (19%). The cumulative positive rates of cTnI at 48 and 72 h after admission were significantly different from those at the first admission and 10-14 days after admission (all P <0.05). Conclusion In the clinical diagnosis of VM onset in children with repeated blood sampling over different time periods, can increase the positive rate of cTnI detection.