小鼠的研究提示,常染色体单基因隐性突变cld 可引起脂蛋白脂酶和肝甘油三酯脂酶活性减低从而影响这些酶在血管内皮表面的功能表达。血浆分解脂肪的作甩可调节导致动脉粥样硬化和抗动脉粥样硬化的脂蛋白水平。了解药物调节这些重要功能的细胞机制可为开发抗心血管疾病有效药物提供理论基础。 Mouse studies suggest that autosomal recessive single gene mutation cld can cause lipoprotein lipase and hepatic triglyceride lipase activity decreased so as to affect the function of these enzymes in vascular endothelial surface expression. The breakdown of plasma lipids can regulate the level of lipoproteins that lead to atherosclerosis and atherosclerosis. Understanding the cellular mechanisms by which drugs regulate these important functions provides a rationale for the development of effective drugs against cardiovascular disease.