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通过炔基化合物捕捉由金催化2-炔基芳基叠氮化合物产生的金卡宾,经串联反应有效合成了3-炔基吲哚.在60℃以2 mol%John Phos Au Cl作为催化剂进行反应,获得了高达94%产率的3-炔基吲哚目标产物.提供了一种非常简单、有效、普适性高的合成3-炔基吲哚的方法.
Synthesis of 3-alkynylindole via a tandem reaction of a gold carbene produced from a gold-catalyzed 2-alkynylaryl azide by an alkynyl compound The reaction was carried out using 2 mol% John Phos AuCl as a catalyst at 60 ° C Yielded the target product of 3-alkynylindole in 94% yield, providing a very simple, effective and ubiquitous method for the synthesis of 3-alkynylindole.