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多发性骨髓瘤(MM)并发肾功能不全者通常不用大剂量化疗,因易产生并发症。作者报道了大剂量化疗后自体外周血干细胞移植(PBSCT)治疗MM伴慢性肾功能不全(CRF)的结果。 病人和方法 MM伴CRF 6例,男女各3例,诊断时中位年龄50岁。移植时,1例完全缓解(CR),3例部分缓解(PR),1例稳定,1例复发,其中4例需作透析治疗(3例血液透析,1例腹膜透析)。诊断至移植中位时间为12个月。干细胞动员用环磷酰胺(CY)25mg/kg·
Patients with multiple myeloma (MM) complicated with renal insufficiency usually do not have large-dose chemotherapy because of complications. The authors report the results of autologous peripheral blood stem cell transplantation (PBSCT) in the treatment of MM with chronic renal insufficiency (CRF) after high-dose chemotherapy. Patients and Methods MM with 6 cases of CRF, 3 cases for men and women, the median age at diagnosis was 50 years old. At the time of transplantation, 1 patient had complete remission (CR), 3 patients had partial remission (PR), 1 patient was stable, and 1 patient had recurrence. 4 patients required dialysis (3 hemodialysis and 1 peritoneal dialysis). The median time from diagnosis to transplantation is 12 months. Stem Cell Mobilization with Cyclophosphamide (CY) 25 mg/kg