肝纤维化(Hepatic fibrosis,HF)是各种慢性肝病向肝硬化发展的必经阶段,是所有慢性肝病的共同病理基础。正常肝脏细胞含有肝细胞、库普弗细胞、肝窦内皮细胞、肝星形细胞(HSC)。在病毒性肝炎、铁铜代谢异常、自身免疫疾病等因素作用下,相关细胞分泌多种细胞因子,如转化生长因子 Hepatic fibrosis (HF) is a necessary stage for the development of various chronic liver diseases to cirrhosis and is the common pathological basis of all chronic liver diseases. Normal liver cells contain hepatocytes, Kupffer cells, sinusoidal endothelial cells, and hepatic stellate cells (HSC). In the viral hepatitis, iron and copper metabolism, autoimmune diseases and other factors, the relevant cells secrete a variety of cytokines, such as transforming growth factor