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目的:探讨血脂控制对原发性高血压患者血压变异性及冠脉事件的影响。方法:以本院2015年1月~2016年8月诊治的158例原发性高血压患者为研究对象,根据血脂控制情况将其分为A(血脂正常)、B(血脂异常)两组,测定比较两组血脂指标、血压变异指标及冠脉事件发生率,并通过Pearson相关性分析血脂水平与血压变异性相关指标的关系。结果:A组患者TC、TG、LDL-C、24h SBPSD、24h DBPSD、24h SBPCV、d SBPCV、n SBPCV、n DBPCV均显著低于B组,HDL-C水平显著高于B组,两组比较差异有统计学意义;A组冠脉事件发生率为16.00%,显著低于B组的33.73%;Pearson相关性分析显示24h SBPSD、24h DBPSD、24h SBPCV、d SBPCV、n SBPCV、n DBPCV与TC、TG显著正相关,24h DBPSD、24h SBPCV与LDL-C显著正相关,24h SBPSD、24h DBPSD与HDL-C显著负相关。结论:血脂异常影响原发性高血压患者血压变异性,增加冠脉事件发生几率,需加强血脂控制以维持患者血压及血压变异性稳定,减少冠脉事件发生。
Objective: To investigate the effect of blood lipid control on blood pressure variability and coronary events in patients with essential hypertension. Methods: A total of 158 essential hypertension patients diagnosed and treated in our hospital from January 2015 to August 2016 were divided into two groups: A (normal blood lipids) and B (dyslipidemia) Blood lipids, blood pressure variability and incidence of coronary events were compared between the two groups. Pearson correlation was used to analyze the relationship between the level of blood lipids and blood pressure variability. Results: The levels of TC, TG, LDL-C, 24h SBPSD, 24h DBPSD, 24h SBPCV, d SBPCV, n SBPCV and n DBPCV in group A were significantly lower than those in group B and HDL-C were significantly higher than those in group B The incidence of coronary events in group A was 16.00%, significantly lower than that in group B (33.73%). Pearson correlation analysis showed that 24h SBPSD, 24h DBPSD, 24h SBPCV, d SBPCV, n SBPCV, n DBPCV and TC , TG significantly positive correlation, 24h DBPSD, 24h SBPCV and LDL-C was significantly positive correlation, 24h SBPSD, 24h DBPSD and HDL-C was significantly negatively correlated. Conclusion: The dyslipidemia affects the variability of blood pressure in patients with essential hypertension and increases the incidence of coronary events. It is necessary to strengthen the control of blood lipids to maintain the stability of blood pressure and blood pressure variability and reduce the occurrence of coronary events.