10例患者中男、女各5例,年龄59～68岁,其症状、体征、X 线胸片和肺功能检查均符合慢支和肺气肿诊断。病程5～50年,均因肺部感染呼衰加重而急诊入院。经抢救病情好转,但仍有低氧血症和二氧化碳潴留。全部患者一次口服阿米脱林(almitrine)150毫克后2小时,口腔闭合压(P_(0.1))由2.67±0.64 Ten patients were male and 5 females, aged 59 to 68 years old, the symptoms, signs, chest X-ray and pulmonary function tests are consistent with chronic bronchitis and emphysema diagnosis. Course of 5 to 50 years, are due to respiratory failure increased respiratory failure and emergency admission. Rescued condition improved, but there are still hypoxemia and carbon dioxide retention. After oral administration of 150 mg of almitrine once a day, oral closure pressure (P_ (0.1)) increased from 2.67 ± 0.64