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【目的】观察应用中药汤剂泄浊逐痹汤联合依托考昔治疗急性痛风性关节炎的临床疗效。【方法】将70例急性痛风性关节炎患者随机分为治疗组和对照组,每组各35例。在基础治疗对等条件下,对照组给予口服依托考昔治疗,治疗组给予内服中药汤剂泄浊逐痹汤联合依托考昔治疗,2组均以7 d为1个疗程。比较2组临床疗效、治疗前后血尿酸、C-反应蛋白(CRP)、血沉等生化指标变化及药物毒副反应情况。【结果】(1)治疗组总有效率为91.4%,对照组为71.4%;治疗组疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者血尿酸、C-反应蛋白及血沉值均明显改善(P<0.05),且治疗组对血尿酸、血沉值的改善作用优于对照组,差异有统计学意义(P<0.05)。(3)对照组3例出现恶心,治疗组未见不良反应,2组比较,差异无统计学意义(P>0.05)。【结论】泄浊逐痹汤联合依托考昔治疗急性痛风性关节炎,在改善临床症状、降血尿酸及血沉方面的疗效优于单纯使用依托考昔。
【Objective】 To observe the clinical efficacy of traditional Chinese medicine decoction Xiezhuobibi Decoction combined with ethafooxi in the treatment of acute gouty arthritis. 【Methods】 Seventy patients with acute gouty arthritis were randomly divided into treatment group and control group, 35 cases in each group. Under the condition of basic treatment equivalence, the control group was given oral reoxycilli treatment, and the treatment group was given orally with Chinese medicine decoction Xiezhuobibi Decoction combined with ethafooxime. Both groups took 7 days as a course of treatment. The clinical curative effect of two groups were compared. The changes of biochemical indexes such as serum uric acid, C-reactive protein (CRP) and erythrocyte sedimentation rate before and after treatment were compared. 【Results】 (1) The total effective rate was 91.4% in the treatment group and 71.4% in the control group. The curative effect in the treatment group was better than that in the control group (P <0.05). (2) After treatment, serum uric acid, C-reactive protein and erythrocyte sedimentation rate in two groups were significantly improved (P <0.05), and the improvement effect of serum uric acid and erythrocyte sedimentation rate in the treatment group was better than the control group, the difference was statistically significant (P <0.05). (3) Nausea was found in 3 cases in the control group, and no adverse reaction was found in the treatment group. There was no significant difference between the two groups (P> 0.05). 【Conclusion】 Xiezhuobibi Decoction combined with ethafooxib in the treatment of acute gouty arthritis has better curative effect in improving clinical symptoms, lowering blood uric acid and erythrocyte sedimentation rate than simply using ethanex.