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用ＨＢｓＡｇ特异性细胞毒性Ｔ淋巴细胞（ＣＴＬ）给ＨＢＶ转基因ＩＣＲ小鼠过继性输注，通过肝组织病理学和免疫组化观察，发现其能诱发类似急性肝炎病变，提示抗原特异性ＣＴＬ在ＨＢＶ抗原所引起的宿主细胞免疫应答而导致肝细胞损伤的过程中有作用。
Using adoptively transfused HBsAg-specific cytotoxic T lymphocytes (CTLs) to HBV transgenic ICR mice, we found that it could induce acute hepatitis-like lesions by histopathology and immunohistochemistry, which suggested that antigen-specific CTL could be expressed in HBV Antigen-induced host cell immune response leading to liver cell damage in the process.