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用结扎双侧颈总动脉合并血压下降法，造成大鼠不完全性脑缺血模型，观察益气活血法对急性缺血脑组织中一氧化氮（ＮＯ）及自由基含量的影响。结果显示，益气组、活血组和益气活血组海马组织ＮＯ含量均低于模型组（Ｐ＜０．０５），３个用药组大脑皮层脑组织过氧化脂质（ＬＰＯ）生成减少（Ｐ＜０．０５，Ｐ＜０．０１，Ｐ＜０．０５），谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性升高（Ｐ＜０．０５，Ｐ＜０．００１，Ｐ＜０．０１），活血组、益气活血组超氧化物歧化酶（ＳＯＤ）活性升高（均为Ｐ＜０．００１）。提示益气法、活血法、益气活血法可能是通过减少缺血脑组织中ＮＯ的生成，减轻ＮＯ介导的神经毒性作用，提高自由基清除酶的活性，抑制脂质过氧化反应，而对缺血性脑组织损伤起保护作用的。
The bilateral common carotid artery with blood pressure drop method was used to establish the model of incomplete cerebral ischemia in rats. The effects of Yiqi Huoxue Method on the content of nitric oxide (NO) and free radical in acute ischemic brain tissue were observed. The results showed that the content of NO in the Yiqi, Huoxue and Yiqihuoxue groups was lower than that in the model group (P <0.05), while the levels of LPO in the cerebral cortex of the three treatment groups decreased (P <0.05, P <0.01, P <0.05), GSH-Px activity increased .01). The activity of superoxide dismutase (SOD) in Huoxue group and Yiqihuoxue group increased (all P <0.001). It is suggested that the method of invigorating qi, activating blood and invigorating qi and promoting blood circulation may reduce the NO-mediated neurotoxicity, reduce the activity of free radical scavenging enzyme and inhibit the lipid peroxidation by reducing NO production in ischemic brain tissue Protects against ischemic brain damage.