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目的调查山西省农村某既往有偿献血地区人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)和乙型肝炎病毒(HBV)合并感染状况。方法对4个村年龄18~59岁的村民进行问卷调查和血样采集,检测项目包括HIV-1抗体、HCV抗体和HBV表面抗原(HBsAg)。结果人群HIV、HCV、HBV感染率分别为1.3%(40/3 062),12.7%(389/3 062),3.5%(103/2982);40名HIV感染者中,85.0%伴HCV感染,2.5%伴HBV感染。多因素Logistic回归分析提示,既往有偿献血(浆)史是HIV、HCV及HIV/HCV合并感染的危险因素,而与HBsAg阳性呈负相关,过去5年外出打工史与HIV、HBsAg、HIV/HCV感染差异有统计学意义;未发现吸毒、终生性伴数、婚外性行为、商业性行为和各种性行为中安全套的使用与HIV、HCV、HBV感染及合并感染有关联。结论应重点关注HIV、HCV和HBV感染者的治疗、健康教育和行为干预。
Objective To investigate the co-infection status of human immunodeficiency virus (HIV), hepatitis C virus (HCV) and hepatitis B virus (HBV) in an area of paid blood donation in rural areas of Shanxi Province. Methods Questionnaires and blood samples were collected from 4 villagers aged 18-59 years. The testing items included HIV-1 antibody, HCV antibody and HBV surface antigen (HBsAg). Results The prevalences of HIV, HCV and HBV in the population were 1.3% (40/3 062), 12.7% (389/3 062) and 3.5% (103/2982), respectively. Among 40 HIV-infected patients, 85.0% 2.5% with HBV infection. Multivariate Logistic regression analysis showed that the history of paid blood donation (plasma) was a risk factor for co-infection of HIV, HCV and HIV / HCV, but negatively correlated with the positive of HBsAg. The history of migrant workers and HIV / HCV, HCV / HCV The differences in infection were statistically significant. No drug addiction, lifetime partners, extramarital sex, commercial sex and the use of condoms in various sexual behaviors were associated with HIV, HCV, HBV infection and co-infection. Conclusion The focus should be on the treatment of HIV, HCV and HBV infection, health education and behavioral interventions.