Central nervous system(CNS)injuries caused by cerebrovascular pathologies(e.g.,stroke)or mechanical contusions(e.g.,traumatic brain injury)disrupt the blood-brain barrier(BBB)that protects the CNS microenvironment from a direct contact with blood substances and cells.The initial neural damage caused by the trauma and the ischemic process Central nervous system (CNS) assemblies caused by cerebrovascular pathologies (eg, stroke) or mechanical contusions (eg, traumatic brain injury) disrupt the blood-brain barrier (BBB) ​​that protects the CNS microenvironment from a direct contact with blood substances and cells. The initial neural damage caused by the trauma and the ischemic process