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目的:比较3种不同麻醉方式在兔神经介入手术中的麻醉效果。方法:新西兰白兔18只，随机分成A、B、C 3组，每组6只，均行右侧颈内动脉支架植入术。A组和B组分别经耳缘静脉注射2%、1%戊巴比妥钠进行麻醉，C组经耳缘静脉注射舒泰n ?50联合皮下注射布托啡诺复合吸入七氟烷维持麻醉。记录3组麻醉相关剂量、麻醉相关时间、麻醉效果评分及麻醉相关并发症。n 结果:所有实验兔神经介入平均手术时间为（71.9±10.2）min。C组首次给药剂量、总剂量、麻醉起效时间、麻醉苏醒时间和麻醉总时长均优于A组和B组（均n P<0.05）。A、B、C组诱导期麻醉评分分别为（3.8±2.3）分、（2.5±1.0）分、（1.0±0.6）分，维持期麻醉评分分别为（3.7±2.6）分、（1.7±1.9）分、（0.3±0.5）分，组间比较差异均有统计学意义（均n P0.05）；而C组诱导期及维持期麻醉评分较A组均显著降低（均n P<0.05）。3组实验兔术中均可维持生命体征稳定并保证合适的麻醉深度。A组、B组、C组分别发生并发症事件7次、3次、2次；C组除1只实验兔发生呼吸抑制外，未出现麻醉期间眼球震颤及激惹等影响手术进程的并发症。n 结论:新西兰白兔神经介入手术中应用舒泰n ?50复合麻醉较戊巴比妥钠单药麻醉效果更好，且并发症少。n “,”Objective:To compare the effects of three anesthesia protocols in rabbit neurointerventional surgery.Methods:Eighteen New Zealand white rabbits were randomized into groups A, B, and C (n n=6 each) and all underwent stenting of the right internal carotid artery. Groups A and B were anesthetized with bolus of 2% and 1% pentobarbital sodium via the marginal ear vein, respectively, while group C was anesthetized by bolus of Zoletiln ?50 via marginal ear vein, hypodermic butorphanol combined with inhaled sevoflurane. The dosage of anesthetics, induction and maintenance time of anesthesia, anesthesia score and anesthesia-related complications were recorded in the three groups.n Results:The mean time of neurointerventional surgery in all experimental rabbits was (71.9±10.2) min. The first dose, total dose, time to anesthesia, recovery time and total duration of anesthesia were more favorable in group C than those in groups A and B (all n P<0.05) . The anesthesia scores in groups A, B, and C were (3.8±2.3) , (2.5±1.0) , and (1.0±0.6) points respectively during the induction, and were (3.7±2.6) , (1.7±1.9) , and (0.3±0.5) points respectively during the maintenance, with statistically significant differences among groups (alln P0.05) ; while the anesthesia scores during induction and maintenance in group C were significantly lower compared with group A (alln P<0.05) . In the three groups of experimental rabbits, stable vital signs were maintained and proper anesthesia depth was secured during the operation. In groups A, B, and C, there were 7, 3 and 2 complication events, respectively. Except for one experimental rabbit in group C suffering respiratory depression, no other complications such as nystagmus and irritation that affect surgical process occurred during anesthesia.n Conclusion:Combined anesthesia using Zoletiln ?50 for neurointerventional surgery in New Zealand white rabbits leads to better anesthesia effect compared with single use of pentobarbital, and is also with fewer complications.n