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目的 :检测与分析 Rb基因表达与胃癌临床病理学特征和预后的关系。方法 :采用 S- P免疫组织化学法检测 5 3例胃癌 Rb基因产物的表达。结果 :胃癌 Rb基因产物表达阳性率 6 0 .4% (32 / 5 3) ,Rb基因产物表达阳性者易发生淋巴结转移 ,生存期短。结论 :检测 Rb基因产物表达有助于胃癌生物学行为的认识及预后的判断。
Objective: To detect and analyze the relationship between Rb gene expression and clinicopathological characteristics and prognosis of gastric cancer. Methods: S-P immunohistochemistry was used to detect the expression of Rb gene in 53 cases of gastric cancer. Results: The positive expression rate of Rb gene product in gastric cancer was 60.4% (32/53). The positive expression of Rb gene product was prone to lymph node metastasis with short survival. Conclusion: Detecting the expression of Rb gene product will be helpful to understand the biological behavior of gastric cancer and prognosis.