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克山病病人尸检材料的电镜与组化观察以及实验动物的病理和生化研究,均提示其心肌中可能存在代谢偏移和供能代谢障碍。我们曾发现云南省楚雄地区1981年度亚急克死亡病人心肌琥珀酸脱氢酶(SDH)和细胞色素氧化酶(CCO)活性明显低于非疾病死亡者。我们再次测定该地区克山病死亡病人心肌呼吸酶活性,共10例(男3,女7)年龄2～10岁,经临床及病理检查证实为亚急克8例;慢克2例,均在死亡后数小时内尸检。取左室心肌组织,液氮保存。并以1982年吉林省非疾病死亡的28例为对照组,均为男性,年龄19～29岁。死亡后2～3小时内尸检,取材及保存同病区组。
Keshan disease patients autopsy material electron microscopy and histochemical observation and experimental animal pathology and biochemical studies, all suggest that there may be myocardial metabolism and energy metabolism disorders. We have found that the activities of succinate dehydrogenase (SDH) and cytochrome oxidase (CCO) in myocardium of patients died of subacute dextrose in Chuxiong of Yunnan Province in 1981 were significantly lower than those of non-disease deaths. We again measured myocardial enzyme activity of Keshan disease death patients in the region, a total of 10 cases (male 3, female 7) age 2 to 10 years old, confirmed by clinical and pathological examination was subacute in 8 cases; Autopsy within hours of death. Take left ventricular myocardial tissue, liquid nitrogen preservation. And in 1982 in Jilin Province, 28 cases of non-disease death as a control group, both men, aged 19 to 29 years. 2 to 3 hours after death, autopsy, drawing and preservation of the same ward group.