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本文分析静脉注射 Nicardipine 对左心室功能和能量利用的影响。方法:对象为13例男性劳力型胸痛患者,平均年龄59(52～70)岁,均无心力衰竭或其它心血管疾病。试验前停服一切心脏活性药物。患者在空腹条件下,经右肱动脉和右肘正中静脉分别插入左、右心导管。待心率血压平稳(±5%),即记录有关参数作为对照。在一分钟内静脉推注尼卡地平2mg,随后以50μg/min 的速度注入本药,并调整剂量使动脉收缩压下降10～20mmHg。15分钟后复查各参数。最后按常规作冠状动脉和左室造影。记录带上的模拟信号用微处理机控制的示波仪进行分析并推导出下列指数:左室压的一阶或二阶时间导数峰值(dP/dt,d~2P/dt~2),主动脉最大流量(Qpeak),主动脉血流加速度峰值(dQ/dtpeak),喷血期功率变化的最大速率按[Q(dP/dt)与 P(dQ/dt)之和的最大值来计算]。左室输出功率峰值等于
This article analyzes the effects of intravenous Nicardipine on left ventricular function and energy utilization. Methods: Thirteen male patients with labor-type chest pain were recruited. The mean age was 59 (ranged from 52 to 70 years). None of them had heart failure or other cardiovascular diseases. Stop taking all cardiac active drugs before the test. Patients under fasting conditions, the right brachial artery and the right elbow median vein were inserted into the left and right heart catheterization. Heart rate blood pressure to be stable (± 5%), that is, the relevant parameters recorded as a control. Intravenous injection of nicardipine 2mg within a minute, followed by injection of the drug at a rate of 50μg / min, and adjust the dose to arterial systolic blood pressure decreased 10 ~ 20mmHg. After 15 minutes review the parameters. Finally, as usual coronary artery and left ventricle angiography. The analog signals on the recording tape were analyzed using a microprocessor-controlled oscilloscope and the following indices were derived: the peak value of the first or second order derivative of left ventricular pressure (dP / dt, d ~ 2P / dt ~ 2) Qpeak, dQ / dtpeak, and the maximum rate of change in ejection power are calculated as the maximum of the sum of Q (dP / dt) and P (dQ / dt) . Left ventricular output peak power equal to