实体瘤低氧区无法获得抗癌药且对放疗耐受,但却为厌氧菌的生长提供了良好的环境。利用厌氧菌趋低氧的特性靶向并破坏肿瘤低氧区,既可作为基因治疗的肿瘤特异载体又可以联合其他治疗增强其抗肿瘤效应。基于厌氧菌的细菌溶瘤治疗具有广阔的前景。 Solid tumor hypoxia can not get anticancer drugs and radiotherapy tolerance, but for the growth of anaerobic bacteria provides a good environment. The use of anaerobic bacteria to hypoxia characteristics targeting and destruction of tumor hypoxia area, both as a gene therapy of tumor-specific carriers can be combined with other treatments to enhance its anti-tumor effect. Anaerobic bacteria based oncolytic treatment has broad prospects.