据Kim TJ 2015年2月12日(e Life,2015,doi:http://dx.doi.org/10.7554/e Life.04876)报道,美国研究人员成功揭示了如何利用机械力来诱导细胞中的关键信号通路。用光学镊子将小珠子吸附到人类干细胞外部后,利用小珠子对干细胞的挤压作用帮助释放细胞中储存的钙离子,并且开启细胞膜中允许离子流入细胞的通道。对干细胞施加机械力会产生一种重要的效应,研究人员据此揭示了干细胞分化背后的许多功能性机制,干细胞周围的机械环 As reported by Kim TJ on February 12, 2015 (e Life, 2015, doi: http://dx.doi.org/10.7554/e Life.04876), U.S. researchers have successfully demonstrated how to use mechanical forces to induce cells The key signal path. Using optical tweezers to adsorb beads to the exterior of human stem cells, the extrusion of the stem cells by the beads helps to release calcium stored in the cells and opens up channels in the cell membrane that allow ions to flow into the cells. The exertion of mechanical force on stem cells has an important effect. Researchers have thus uncovered many of the functional mechanisms behind stem cell differentiation, the mechanical loops around stem cells