用 NADPH脱氢酶反应 ,观察了大鼠大脑中动脉缺血再灌流模型中海马及纹状体一氧化氮合酶 (NOS)阳性神经元的变化及 IL- 6对这些变化的影响。结果显示 :缺血再灌流后大鼠海马各部 NOS阳性神经元均明显增加 ,其中以CA1区增加最显著 ,纹状体缺血中心区 NOS阳性神经元明显减少 ,而其周围区 NOS阳性神经元明显增加 ,预先经侧脑室注射 IL- 6后 ,大鼠海马及纹状体 NOS阳性神经元数量明显低于对照组。提示 IL- 6可能参与缺血性神经元损伤的调控。 NADPH dehydrogenase reaction was used to observe the changes of nitric oxide synthase (NOS) positive neurons in hippocampus and striatum of rat middle cerebral artery occlusion (MCAO) model and the effect of IL-6 on these changes. The results showed that NOS positive neurons in hippocampus of rats were significantly increased after ischemia-reperfusion, and the most significant increase was in CA1 area. NOS positive neurons in central area of ​​striatum were significantly decreased, but NOS positive neurons The number of NOS positive neurons in the hippocampus and striatum was significantly lower than that of the control group after IL-6 injection into the lateral ventricle. It is suggested that IL-6 may be involved in the regulation of ischemic neuronal injury.