一种通用的随机近似法已被用来求单点、单剂量法以分别估计浸入率和血清药物的浓度。通过采用随机密度函数的变换,在药理性可变情况下以消去率恒定的变化,人们研究了变化的影响以及可选择最优的采样时间。通过这一研究把事件看作具有恒定分布率的信号器发出的随机信号。该方法可扩展到更一般的情况。依据少数样本的检测而提出的单剂量的要求在近几年里已引起了人们的重视。在估计剂量或药物浓度时通常用到平均的或是标定的药理 A common stochastic approximation has been used to find a single point, single dose method to estimate the rate of penetration and the concentration of serum drug, respectively. By using a transformation of random density function, with a constant change in elimination rate under pharmacologically variable conditions, one investigates the effect of the change and the choice of the optimal sampling time. Through this research, we regard the event as a stochastic signal from an annunciator with a constant distribution rate. This method can be extended to more general case. The request for a single dose based on the detection of a few samples has drawn much attention in recent years. Averaging or calibrated pharmacology is commonly used when estimating dosages or drug concentrations