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采用氧氟沙星（ＯＦＬＸ）阴道泡腾片和诺氟沙星（ＮＦＬＸ）阴道栓对临床常见的细菌性阴道炎进行了动物体内外抗菌活性测定。结果显示：体外测定组：ＯＦＬＸ对致病菌的ＭＩＣ在０１～３１２μｇ／ｍｌ而ＮＦＬＸＭＩＣ与其相近。体内测定组：ＯＦＬＸ的治愈率２ｍｇ／ｋｇ组为５０％，４ｍｇ／ｋｇ和８ｍｇ／ｋｇ组为１００％。而ＮＦＬＸ栓２ｍｇ／ｋｇ组为４０％，４ｍｇ／ｋｇ组为８０％，８ｍｇ／ｋｇ组为１００％，空白组治愈率为０。说明ＯＦＬＸ阴道泡腾片对此类阴道炎具良好的疗效，低、中剂量组略优于ＮＦＬＸ栓。但两药无统计学差异
OFLX vaginal effervescent tablets and norfloxacin (NFLX) vaginal suppository were used to determine the antibacterial activities in vivo and in vitro of common bacterial vaginosis. The results showed that in vitro assay group: OFLX against pathogens MIC in 0 1 ~ 3 12μg / ml and NFLXMIC similar. In Vivo Assay Groups: The cure rates for OFLX were 50% for the 2 mg / kg group and 100% for the 4 mg / kg and 8 mg / kg groups. The NFLX suppository was 40% in the 2 mg / kg group, 80% in the 4 mg / kg group and 100% in the 8 mg / kg group, with a cure rate of 0 in the blank group. OFLX vaginal effervescent tablets have such a good effect on the treatment of vaginitis, low, medium dose group was slightly better than NFLX suppository. However, there is no statistical difference between the two drugs