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目的 研究IFN+2-2-1程序和2-2-1程序应用的可行性，探讨IFN的免疫调节作用。方法 IFN+2-2-1程序：于0、7、14天分别注射5.0、5.0、2.5IU PHKCV，于0天同时加注20万IUα-IFN；2-2-1程序：于0、7、14天分别注射5.0、5.0、2.5IUPHKCV；对照：应用WHO推荐的常规程序。结果 ①3种程序免疫后的GMT：7天时分别为1.71、1.57、1.21(*P<0.05)；14天时分别为62.77、58.79、28.96**(**P<0.01)；45天时分别为76.64、72.90、62.77。②各组的阳转率：7天时分别为55.00％、33.3％、20.00％*(*P<0.05)；14天时全部达到100％。③各组的各种副反应发生率(在0～55％之间)均无显著性差别。结论 小剂量的IFN有增强免疫应答的作用；首次免疫时用双倍剂量的疫苗有显著的高免疫应答效应；IFN+2-2-1程序优于2-2-1程序，后者又优于常规程序。“,”Aim To study the possibility of using IFN + 2-2-1schedule and 2-2-1schedule , and to discuss the mechanism of the regultion of immunuity of IFN. Methods The IFN + 2-2-1 schedule: Injecting 5.0, 5.0, 2.5IU PHKCV on the 0, 7th and 14th day respectively and injecting 0.2 million IU IFN-α simultaneously on the 0 day. The 2-2-1 schedule: Injecting 5.0, 5.0, 2.5IU PHKCV on the 0, 7th, 14th day respectively. Control group: Using the routine schedule recommended by WHO.Results (①)TheGMTofeachgroupwas1.71, 1.57, 1.21* (*P<0.05) respectively on the 7th day, 62.77, 58.79, 28.96** (* *P <0.01) respectively on the 14th day, and 76.64, 72.9, 67.22 respectively on the 45th day.(②)The positive rate of antibody of each group was 55.00%, 33.33%, 20.00%* (*P, 0.05) respectively on the 7th day and became100 % all on the 14th day. (③) The rate of each kind of side reaction of each group was between 0 and 55%, but there wos no significant difference. Conclusion rnLower dose of IFN had the effect of enhancing immunization. The double dose of vaccine when firstly immunizing had the higher effect of immune response. The IFN + 2-2-1 schedule was better than the 2-2-1 schedule, while the 2-2-1 schedule was better than the routine schedule.