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目的观察Survivin、PTEN和GPC3在肝细胞癌中的表达,探讨其在肝细胞癌发生、发展中的作用。方法应用免疫组织化学Envision法检测Survivin、PTEN和GPC3在40例肝细胞癌、40例癌旁组织及20例正常肝组织中的表达。结果 Survivin及GPC3蛋白在肝细胞癌中表达分别为62.5%、82.5%;显著高于癌旁组织(22.5%、5%)及正常肝组织(0);PTEN蛋白在肝细胞癌、癌旁及正常肝中表达分别为47.5%、92.5%、97.5%,其在肝癌组织的表达水平显著低于癌旁组织和正常肝组织。结论 Survivin、PTEN和GPC3蛋白异常表达与肝细胞癌的发生和发展有密切关系。
Objective To investigate the expression of Survivin, PTEN and GPC3 in hepatocellular carcinoma (HCC) and to explore the role of Survivin, GPCR and GPC3 in the occurrence and development of hepatocellular carcinoma. Methods The expressions of Survivin, PTEN and GPC3 in 40 hepatocellular carcinomas, 40 paracancerous tissues and 20 normal liver tissues were detected by Envision immunohistochemistry. Results The expressions of Survivin and GPC3 in hepatocellular carcinoma were 62.5% and 82.5%, respectively, which were significantly higher than those in paracancerous tissues (22.5% and 5%) and normal liver tissues (0) The expression in liver was 47.5%, 92.5% and 97.5%, respectively, which was significantly lower in HCC tissues than in paracancer tissues and normal liver tissues. Conclusion The abnormal expressions of Survivin, PTEN and GPC3 are closely related to the occurrence and development of hepatocellular carcinoma.