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目的检测Survivin和PTEN在肺癌中的表达,探讨两者在肺癌中的意义及关系。方法利用S P免疫组化法检测62例肺癌标本和10例正常肺标本中Survivin和PTEN表达情况。结果62例肺癌中Survivin和PTEN阳性率分别为56.5%和41.9%,正常肺组织中Survivin和PTEN阳性率分别为0和90.0%。Survivin在肺癌组织中的表达显著高于正常肺组织(P<0.01),Survivin的表达与淋巴结转移和临床分期相关(P<0.05);PTEN在正常组织的表达显著高于肺癌组织(P<0.01),与淋巴结转移和临床分期相关(P<0.01)。Survivin和PTEN两者表达强度之间呈显著负相关(P<0.01)。结论Survivin在肺癌中过表达,PTEN在肺癌中表达减低,PTEN可下调Survivin的表达。Sur- vivin在肺癌发展中起促进作用,PTEN起保护作用,两者与肺癌的侵袭性和预后有一定关系。
Objective To detect the expression of Survivin and PTEN in lung cancer and to explore their significance and relationship in lung cancer. Methods The expressions of Survivin and PTEN in 62 lung cancer specimens and 10 normal lung specimens were detected by SP immunohistochemical method. Results The positive rates of Survivin and PTEN in 62 cases of lung cancer were 56.5% and 41.9%, respectively. The positive rates of Survivin and PTEN in normal lung tissues were 0 and 90.0% respectively. The expression of Survivin in lung cancer tissues was significantly higher than that in normal lung tissues (P <0.01). Survivin expression was correlated with lymph node metastasis and clinical stage (P <0.05). The expression of PTEN in normal tissues was significantly higher than that in lung cancer tissues ), And lymph node metastasis and clinical stage (P <0.01). There was a significant negative correlation between the expression of Survivin and PTEN (P <0.01). Conclusion Survivin is overexpressed in lung cancer, PTEN is down-regulated in lung cancer, and PTEN down-regulates Survivin expression. Survivin plays a role in the development of lung cancer and PTEN plays a protective role. Both of them have some relationship with the invasiveness and prognosis of lung cancer.