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目的:探讨急性心肌梗死(AMI)患者外周血红蛋白含量、白细胞计数及血脂变化的临床意义。方法:对113例AMI患者应用美国库尔特JT血球计数器测定血红蛋白(Hb)含量、白细胞(WBC)数、中性粒细胞百分率(N%)、中性粒细胞绝对值(N)、淋巴细胞百分率(L%)、淋巴细胞绝对值(L)及血脂含量,结合冠状动脉造影(冠脉造影)及超声心动图检查,观察Hb含量、WBC数及血脂水平与冠状动脉硬化、AMI的相关性。结果:AMI患者外周血中Hb含量较正常对照组及心绞痛(AP)组显著增加(P<0.05)。四分位法研究AMI组Hb含量位于最高1/4位者较最低1/4位者显著增加(P<0.05)。AMI组Hb含量位于最高1/4位者较AP组显著增加(P<0.05)。Hb含量位于最高1/4位者发生AMI者较Hb含量位于最低1/4位者显著增加(P<0.05);AMI组WBC、N%、N、M%、M较正常对照组及心绞痛(AP)组显著增加(P<0.05),L较正常对照组显著降低(P<0.05);AMI组TG正常而对照组显著增加(P<0.05),AMI组TC≥5.72 mmol/L者占16.46%,TC>5.2 mmol/L者占31.3%;TG≥1.7 mmol/L者占46.34%;LDL≥3.12 mmol/L者占11.25%;HDL<0.91 mmol/L者占6.25%;总的血脂异常率为80.3%。但AMI及AP两组间血脂各项指标无显著性差异。冠状动脉造影显示AMI组冠状动脉狭窄≥95%及冠状动脉闭塞病变的发生率显著高于AP组,冠状动脉闭塞组Hb含量(150.92±13.11)g/L显著高于无冠状动脉闭塞组(139.98±13.11)g/L(P<0.05)。而冠状动脉闭塞组与冠状动脉非闭塞组之间血脂含量无显著性差异。结论:白细胞计数及血红蛋白含量均与AMI有关,其中血红蛋白还与冠脉狭窄冠脉闭塞有关。血红蛋白增高应作为AMI的危险因子受到重视。
Objective: To investigate the clinical significance of peripheral hemoglobin, white blood cell count and serum lipids in patients with acute myocardial infarction (AMI). Methods: The hemoglobin (Hb), the number of white blood cells (WBC), the percentage of neutrophils (N%), the absolute value of neutrophils (N), lymphocytes (L%), absolute value of lymphocyte (L), and blood lipid content were measured. Coronary angiography (CAG) and echocardiography were used to examine the correlation between Hb level, WBC count and serum lipids and coronary atherosclerosis and AMI . Results: The content of Hb in peripheral blood of AMI patients was significantly higher than that of normal control group and angina pectoris group (P <0.05). In the quartile study, the AMI patients whose Hb content was in the upper 1/4 was significantly higher than the lowest one-fourth (P <0.05). AMI group Hb content in the highest 1/4 than in AP group was significantly increased (P <0.05). Compared with the control group and the angina pectoris group (P <0.05), the WBC, N%, N, M% and M in the AMI group were significantly higher than those in the AMI group AP group (P <0.05), L was significantly lower than the normal control group (P <0.05); AMI group TG normal control group increased significantly (P <0.05), AMI group TC≥5.72 mmol / L accounted for 16.46 %, TC> 5.2 mmol / L accounted for 31.3%; TG≥1.7 mmol / L accounted for 46.34%; LDL≥3.12 mmol / L accounted for 11.25%; HDL <0.91 mmol / L accounted for 6.25%; total dyslipidemia The rate is 80.3%. However, there was no significant difference between the two groups in AMI and AP. Coronary angiography showed that the incidence of coronary stenosis≥95% and coronary occlusion in AMI group was significantly higher than that in AP group. The content of Hb in coronary occlusion group (150.92 ± 13.11) g / L was significantly higher than that in non-coronary occlusion group (139.98 ± 13.11) g / L (P <0.05). The coronary occlusion group and non-occlusion of coronary artery blood lipid content was no significant difference. Conclusion: Leukocyte count and hemoglobin content are all related to AMI, and hemoglobin is also involved in coronary artery occlusion. Hemoglobin increase should be taken as a risk factor for AMI attention.