论文部分内容阅读
为进一步研究酸在非类固醇抗炎药(NSAID)所致损伤中的意义,作者研究了奥美拉唑(Ome)抑酸治疗对健康志愿者长期(2周)服用阿司匹林所致胃粘膜损伤的作用。 材料和方法:20名健康志愿者随机分服Ome(40 mg/d)或安慰剂加阿司匹林(650 mgqid)2周。服药前每位志愿者接受内镜检查以检查粘膜的完整性。第15天(服药结束后次日)再作内镜检查,评估胃、十二指肠损伤。然后,在药物“清除”2周后,再次作内镜检查,再交叉
To further investigate the role of acid in the injury caused by NSAIDs, we investigated the effect of ometric acid suppression therapy on gastric mucosal damage induced by aspirin in healthy volunteers over a long (two-week) period effect. MATERIALS AND METHODS: Twenty healthy volunteers were randomized to Ome (40 mg / d) or placebo plus aspirin (650 mgqid) for 2 weeks. Each volunteer received an endoscopy before medication to check mucosal integrity. On the 15th day (the day after the medicine was taken), endoscopy was performed to evaluate the gastric and duodenal injury. Then, after the drug was “cleared” for 2 weeks, it was again examined by endoscopy and then crossed