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目的通过对各类脑血管病（ＣＶＤ）患者血浆内皮素（ＥＴ）含量的动态变化的测定观察，进一步揭示ＥＴ与各类ＣＶＤ的发生、发展的关系。方法本研究动态观测了９５例脑梗塞患者、５７例脑出血患者及２７例蛛网膜下腔出血患者血浆ＥＴ含量的变化。结果（１）各类ＣＶＤ患者血浆ＥＴ水平明显高于对照组（Ｐ＜０００１）。（２）ＣＶＤ患者发病后２４ｈ内血浆ＥＴ水平即开始升高，发病后１～３天或４～７天达高峰，半月后开始下降，１月后降至较正常水平稍高或正常。结论本研究结果表明，ＣＶＤ后ＥＴ升高的过程与ＣＶＤ后缺血半暗带，脑水肿及脑血管痉挛的发生时程一致。说明ＥＴ参与了ＣＶＤ的发生、发展
Objective To investigate the dynamic changes of endothelin (ET) in patients with various types of cerebrovascular disease (CVD) and further reveal the relationship between ET and the occurrence and development of various types of CVD. Methods The present study dynamically observed changes in plasma ET levels in 95 patients with cerebral infarction, 57 patients with cerebral hemorrhage and 27 patients with subarachnoid hemorrhage. Results (1) Plasma ET levels in all types of CVD patients were significantly higher than those in the control group (P <0001). (2) Plasma ET levels began to increase within 24 hours after onset of CVD in patients with CVD, reaching peak at 1 ~ 3 days or 4 ~ 7 days after onset, then decreasing after half a month, then decreasing to normal or slightly higher than normal after January. Conclusions The results of this study indicate that the process of ET elevation after CVD is consistent with the development of ischemic penumbra, cerebral edema and cerebral vasospasm after CVD. ET involved in the occurrence and development of CVD