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分析临床表现为原发性肾病综合征的微小病变肾病（ＭＣＤ）、ＩｇＭ肾病（ＩｇＭＮ）和非ＩｇＡ、ＩｇＭ系膜增殖性肾炎（ＭｓＰＧＮ）病理改变（微机定量图像分析）和临床表现的联系。发现：（１）３种疾病以ＩｇＭＮ发生率最高（４８．８９％），一过性肾功损害、激素依赖比例以ＭｓＰＧＮ为高，ＩｇＭＮ、ＭｓＰＧＮ存在明显血尿；（２）病理定量分析表明：ＩｇＭＮ和ＭｓＰＧＮ的系膜细胞数、系膜基质增宽及间质改变较ＭＣＤ明显增高（Ｐ＜０．０１），ＭｓＰＧＮ系膜区增宽比ＩｇＭＮ更明显（Ｐ＜０．０１）；（３）ＩｇＭＮ、ＭｓＰＧＮ间质病变越重，越易伴有高血压、血尿、一过性肾功损害和激素依赖，其中以ＭｓＰＧＮ更明显。表明ＩｇＭＮ肾病预后相对较好，而ＭｓＰＧＮ相对较差。
To analyze the relationship between clinical manifestations and pathological changes of micro-lesion nephropathy (MCD), IgM nephropathy (IgMN) and non-IgA, IgM mesangial proliferative glomerulonephritis (MsPGN) with clinical manifestations of primary nephrotic syndrome. The results showed that: (1) The highest incidence of IgMN (48.89%), transient renal damage, hormone-dependent ratio of MsPGN, IgMN, MsPGN were found in all three diseases. (2) The number of mesangial cells, mesangial matrix enlargement and interstitial changes of IgMN and MsPGN were significantly higher than those of MCD (P <0.01), and the width of mesangial area of MsPGN was more obvious than that of IgMN (P <0.01) ) IgMN, MsPGN interstitial lesions heavier, more likely to be associated with hypertension, hematuria, transient renal damage and hormone dependence, which MsPGN more obvious. The prognosis of IgMN nephropathy is relatively good, while MsPGN is relatively poor.