为探讨肿瘤坏死因子(TNFa)在细菌性脑膜炎致病机理中的作用,测定了50例细菌性脑膜炎患者脑脊髓液(CSF)中TNFa的含量,结果表明90％(45/50)细菌性脑膜炎患者CSF中TNFa含量升高(>64pg/ml),其中以化脓性脑膜炎升高最为显著,提示TNFa直接参与了细菌性脑膜炎的致病过程。而非细菌性脑膜炎患者CSF中TNFa含量并不上升。因此检测中枢神经系统感染患者CSF中TNFa含量不失为一项较好的鉴别细菌性和非细菌性脑膜炎的指标。 To investigate the role of tumor necrosis factor (TNFa) in the pathogenesis of bacterial meningitis, the levels of TNFa in cerebrospinal fluid (CSF) of 50 patients with bacterial meningitis were determined. The results showed that 90% (45/50) of bacteria The level of TNFa in CSF of patients with meningitis increased (> 64pg / ml), of which the most significant increase in purulent meningitis, suggesting that TNFa directly involved in the pathogenesis of bacterial meningitis. TNFa levels did not increase in CSF of patients with bacterial meningitis. Therefore, detection of TNFa in the CSF of patients with central nervous system infection is a good indicator to distinguish between bacterial and non-bacterial meningitis.