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目的:探讨半夏泻心汤及其有效组份黄连素对幽门螺杆菌(Hp)感染相关性胃炎胃黏膜的保护作用。方法:采用灌胃造模的方法建立Hp感染相关性胃炎动物模型,检测用半夏泻心汤及其有效组份黄连素治疗后胃黏膜炎性细胞浸润程度和血清中表皮生长因子(EGF)含量变化。结果:全方组和黄连素组治疗后炎细胞浸润程度明显减轻;模型组血清EGF含量显著下降(P<0.05),与模型组比较,全方组小鼠血清中EGF含量升高(P<0.05);黄连素组与模型组EGF含量比较,差异无显著性意义(P>0.05)。结论:半夏泻心汤及其有效组份黄连素可减轻胃黏膜的炎症反应;半夏泻心汤通过上调感染小鼠机体血清EGF含量而实现对胃黏膜的保护作用。
Objective: To investigate the protective effect of Banxia Xiexin Decoction and its effective component berberine on the gastric mucosa of Helicobacter pylori (Hp) infection-associated gastritis. METHODS: An animal model of Hp infection-associated gastritis was established by intragastric administration. The extent of inflammatory cell infiltration and serum epidermal growth factor (EGF) after treatment with Banxia Xiexin Decoction and its effective component berberine were determined. Changes in content. RESULTS: The inflammatory cell infiltration was significantly reduced after treatment in all groups and berberine group; serum EGF levels in the model group were significantly decreased (P<0.05). Compared with the model group, serum EGF levels in the whole group increased (P< 0.05); EGF content of berberine group and model group, the difference was not significant (P> 0.05). Conclusion: Banxia Xiexin Decoction and its effective component berberine can reduce the inflammatory response of gastric mucosa; Banxia Xiexin Decoction can protect the gastric mucosa by up-regulating the serum EGF content of infected mice.