吸入糖皮质激素是目前维持哮喘疗效的重要治疗方法。长期全身应用激素不可避免引起骨代谢平衡失调 ,使人体多个部位含小梁结构骨的骨密度(BMD)降低 ,甚至导致骨质疏松。尽管吸入疗法已经大大减少了骨的副效应 ,但较大剂量吸入激素仍会抑制骨形成或增加骨吸收 [1]。为评价长期吸 Inhaled glucocorticoid is an important treatment to maintain the efficacy of asthma. Long-term systemic application of hormones inevitably lead to imbalance of bone metabolism, so that multiple parts of the body with trabecular bone mineral density (BMD) decreased, and even lead to osteoporosis. Although inhaled therapy has greatly reduced bone side effects, higher doses of inhaled hormones may still inhibit bone formation or increase bone resorption [1]. For long-term evaluation of smoking