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给小鼠iv和ig国产湿痛喜康,LD_(50)分别为135±10.27和320±96mg/kg。给佐剂性关节炎大鼠ig湿痛喜康28d,体重增加,血清AKP、SGPT和BUH无明显改变。病解无明显形态学变化。给3条狗ig湿痛喜康16mg/kg, 每天1次,连用5d,两条中毒死亡,1条存活。另3条狗ig湿痛喜康16mg/kg,隔日1次,自首剂给药后10～20d达到稳态中毒血药浓度(分别为73.9,44.9,72.5μg/ml)。于给药后17～25d死亡。出凝血时间延长约2～3倍,血浆BUN值升高。病检除1条狗可见间质性肾炎和肝细胞局灶性坏死外,其余未见明显特征性改变,给大鼠ig湿痛喜康(5、10、20和40mg/kg),对消化道有损伤作用。UD_(50)为14.75mg/kg(95％可信区间为19.4～19.93mg/kg),与血药浓度呈平行关系。
To mice iv and ig domestic wet pain Xikang, LD_ (50) were 135 ± 10.27 and 320 ± 96mg / kg. Adjuvant arthritis rats ig wet pain Xikang 28d, weight gain, serum AKP, SGPT and BUH no significant change. Disease solution no obvious morphological changes. To three dogs ig wet pain Xikang 16mg / kg, 1 day, once every 5d, two poisoning death, a surviving. The other three dogs ig wet pain Xikang 16mg / kg, every other day 1, from the first dose after 10 ~ 20d reached steady-state poisoning plasma concentrations (73.9,44.9,72.5μg / ml respectively). After dosing 17 ~ 25d died. The clotting time to extend about 2 to 3 times, plasma BUN value increased. In addition to a disease can be found in a dog interstitial nephritis and focal hepatic cell necrosis, the other no significant change in the characteristics of the rat ig wet pain (5,10,20 and 40mg / kg) digestion Road damage. UD_ (50) was 14.75mg / kg (95% confidence interval 19.4 ~ 19.93mg / kg), and the plasma concentration was in parallel.