环孢菌素(CyA)是从真菌分离到的环寡肽。临床中用作器官移植病人的免疫抑制剂及治疗自身免疫失调。它在人体和动物体内进行广泛代谢,肌汁是人体和动物体内CyA 代谢物的主要通道。为建立一个从肝移植病人胆汁中分离纯的CyA 代谢物的方法和鉴定病人胆汁中主要的代跗物,作者在4例接受CyA 治疗的肝移植病人的胆汁乙醚萃取物中分离到10个代谢产物,其中2个是未报道过的新型代谢产物(B和G)。实验方法是首先用乙醚提取胆汁,减 Cyclosporine (CyA) is a cyclic oligopeptide isolated from fungi. Immunosuppressive agents for the treatment of organ transplant patients and the treatment of autoimmune disorders in clinical settings. It is widely metabolized in both human and animal body, and muscle juice is the main channel for CyA metabolites in humans and animals. To establish a method for the isolation of pure CyA metabolites from the liver transplant patient’s bile and to identify the major surrogate of the patient’s bile, the authors isolated 10 metabolites from bile ether extracts from 4 liver transplant patients treated with CyA Two of the products were novel metabolites (B and G) that were not reported. The experimental method is to first extract the bile with ether, minus