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复方黄连素注射液中含甲氧苄氨嘧啶(TMP)和硫酸黄连素两种成分,通常硫酸黄连素的含量测定采用比色法[吉林省药品标准1986:361],而TMP 的含量测定需经过多次提取分离,操作烦琐费时。本文采用双波长分光光度法可不经分离直接测定二组分含量。现介绍如下:一、仪器与试药751—型分光光度计(上海分析仪器厂);TMP硫酸黄连素均为注射用;辅料符合药用规格(公主岭市制药厂提供);复方黄连素注射液为市售;试剂为分析纯.
Compound berberine injection containing trimethoprim (TMP) and berberine sulfate two components, usually berberine sulfate content determination using colorimetry [Jilin Province Drug Standards 1986: 361], while the determination of TMP content After repeated extraction separation, cumbersome and time-consuming operation. In this paper, two-wavelength spectrophotometry can be directly measured without separation of two components. Now introduced as follows: First, instruments and reagents 751-type spectrophotometer (Shanghai Analytical Instrument Factory); TMP sulfate berberine are for injection; accessories meet the pharmaceutical specifications (Gongzhuling Pharmaceutical Factory); compound berberine injection Is commercially available; reagents are of analytical grade.