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目的:探讨口服高渗氯化钠维生素C液对腹腔感染的治疗作用。方法:选择雄性wister大鼠60只,随机分为4组,各组均行盲肠结扎穿孔手术造模,术后分别灌以生理盐水、高渗氯化钠液、维生素C、高渗氯化钠维生素C液。采集门静脉血测定内毒素含量,取回肠末段行病理学观察,并测定肠组织MDA、SOD、羟自由基的含量。结果:高渗氯化钠维生素C液治疗组疗效最好。含维生素C治疗液组(VC组与HSVC组)与不含维生素C成分组(HNS组和NS组)相比SOD活性显著提高,具有统计学意义(P<0.05)。含高渗氯化钠成分治疗液组(HSVC组和HNS组)与不含有高渗氯化钠成分的组(VC组和NS组)相比抑制羟自由基的能力显著提高,具有统计学意义(P<0.05)。结论:高渗氯化钠维生素C对腹腔感染大鼠肠屏障有较明显的保护作用。
Objective: To investigate the therapeutic effect of oral hypertonic sodium chloride vitamin C solution on abdominal infection. Methods: Sixty male Wister rats were randomly divided into 4 groups. Each group underwent cecum ligation and perforation. After operation, they were infused with saline, hypertonic sodium chloride solution, vitamin C, hypertonic sodium chloride Vitamin C solution. Portal venous blood samples were collected to determine endotoxin content, and pathological examination was performed to determine the content of MDA, SOD and hydroxyl radical in intestinal tissue. Results: Hypertonic sodium chloride vitamin C solution group the best effect. The activity of SOD in vitamin C treatment group (VC group and HSVC group) was significantly higher than that in vitamin C group (HNS group and NS group), with statistical significance (P <0.05). The ability to inhibit the hydroxyl radical in the treatment group (HSVC group and HNS group) and the group without hypertonic sodium chloride (VC group and NS group) were significantly increased with statistical significance (P <0.05). Conclusion: Hypertonic sodium chloride vitamin C has obvious protective effect on intestinal barrier in rats with abdominal infection.