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目的 :研究绝经妇女在使用长效雌三醇治疗 3年后生殖内分泌的功能状况。方法 :用放射免疫分析 (RIA)测定了 136例自然绝经后的妇女 (绝经时间为 1～ 5年 ) ,4 8例绝经后 ,用长效雌三醇作激素替代治疗3年的妇女 ,以及 131例正常育龄妇女卵泡期和黄体期血清的六项生殖激素FSH、LH、PRL、T、E2 、P的水平。结果 :正常育龄妇女无论是卵泡期 ,还是黄体期 ,血清的六项生殖激素FSH、LH、PRL、T、E2 、P的水平与绝经后妇女相比较 ,均有非常显著性差异 (所有p<0 0 1;除了 1例绝经后妇女为泌乳素血症外 )。绝经后妇女在使用长效雌三醇治疗 3年后 ,FSH、LH和PRL的水平都明显降低 ,有非常显著性差异 (p <0 0 0 1)而其中以FSH和LH的降低幅度为最大 ,更年期综合征的临床症状亦随之改善。而E2 、P、T水平变化不大 ,无显著性差异 (p >0 0 5 )。结论 :测定生殖激素水平在中老年妇女的雌激素替代治疗中具有非常重要的意义。
OBJECTIVE: To investigate the functional status of postmenopausal women for reproductive endocrinology after three years of treatment with long-acting estriol. METHODS: Thirty-six women with postmenopausal women (menopause time 1-5 years) were assayed by radioimmunoassay (RIA), 48 women postmenopausal with long-acting estriol as hormone replacement therapy for 3 years, and The levels of FSH, LH, PRL, T, E2, P of six reproductive hormones in 131 normal women of childbearing age in serum of follicular phase and luteal phase. Results: The levels of FSH, LH, PRL, T, E2 and P of the six reproductive hormones in normal women of childbearing age were significantly different from those in postmenopausal women (all p < 0 0 1; except one case of postmenopausal women with prolactinemia). Postmenopausal women with long-acting estriol after 3 years of treatment, FSH, LH and PRL levels were significantly lower, there was a significant difference (p <0 0 0 1) and the reduction of FSH and LH were the largest , The clinical symptoms of menopausal syndrome also will be improved. The levels of E2, P and T did not change significantly (p> 0.05). Conclusion: The determination of reproductive hormone levels in the elderly women estrogen replacement therapy has a very important significance.