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目的 以单光子发射计算机断层仪 SPECT作为诊断依据 ,建立兔应力性骨折 (stress fracture,SF)实验模型 ,观察并探讨 SF发生过程中骨骼及骨骼肌形态的变化 .方法 10只兔作为实验组 ,4只作为对照组 .实验组置于模拟实验装置内 ,使动物产生跑跳运动 .每天跑跳有效次数约 30 0次 . 1wk训练 6 d,共 6 wk.于运动不同时间分别取阳性骨组织和腓肠肌组织行病理学观察 .结果 1肉眼可见实验组病变部位骨骼较对照侧突起、肿胀 ,触之较硬 . 2随着运动天数的延长 ,光镜下病变部位骨骼损害加重 . 3连续观察结果发现 ,运动第 2~ 3周肌纤维损伤最为严重 .结论 在 SF发生过程中 ,骨骼肌组织出现损害的日期早于骨组织 ,说明骨骼肌肉的损害很可能是引起 SF发生的原因
Objective To establish a experimental model of stress fracture (SF) in rabbits by using single-photon emission computed tomography (SPECT) as a diagnostic basis and to observe the morphological changes of skeletal and skeletal muscle during the development of SF.Methods 10 rabbits were used as the experimental group, 4 as a control group.The experimental group was placed in a simulated experimental device, the animals produce running jogging.Every day, the effective number of running jumped about 30 0 1wk training 6 d, a total of 6 wk.On the exercise at different times were positive bone tissue And the gastrocnemius muscle tissue were observed by pathology.Results1 The bones of the diseased part of the experimental group protruded, swollen and toughened more than those of the control side.2 The skeletal damage of the lesion under the light microscope was aggravate.3 The result of continuous observation Found that the most severe muscle fibers were damaged in the second to third week of exercise.Conclusion The occurrence of skeletal muscle tissue was earlier than that of bone tissue during the process of SF, indicating that the damage of skeletal muscle is likely to be the cause of SF