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利用光镜、免疫组织化学方法，并利用ＰＣＶＩＳＩＯＮ８５ＰＬＵＳ计算机对脾切片进行图像分析，探讨缺碘、补碘及长期缺碘原代鼠脾的形态学变化。结果观察到由于碘影响甲状腺激素水平进而影响脾的结构与功能。根据边缘区的结果．低碘引起免疫能力下降，补碘后免疫能力增强，长期缺碘有可能引起自身的免疫作用。
The spleen sections were analyzed by light microscopy, immunohistochemistry and PCVISION85PLUS computer to investigate the morphological changes of spleen in iodine deficiency, iodine deficiency and chronic iodine deficiency primary rats. As a result, iodine was found to affect the structure and function of the spleen due to the effects of iodine on thyroid hormone levels. According to the results of the marginal zone. Low iodine caused decreased immunity, immune capacity increased after iodine supplementation, long-term iodine deficiency may cause their own immune function.