论文部分内容阅读
在盐酸莫西沙星的研究过程中,发现了一个新的有关物质,在成品中含量为0.1%左右。用制备型高效液相色谱对其进行分离纯化,通过元素分析、质谱和核磁共振谱(包括1H NMR,H-H cosy,13C NMR,DEPT,HSQC,HMBC)确定其结构为1-环丙基-7-(1-氨基-8-氮杂双环[4.3.0]壬烷-8-基)-6-氟-8-甲氧基-1,4-二氢-4-氧代-3-喹啉羧酸。
In the course of the research of moxifloxacin hydrochloride, a new related substance was found which contained about 0.1% of the finished product. The compounds were separated and purified by preparative HPLC and their structures were confirmed to be 1-cyclopropyl-7 by elemental analysis, mass spectrometry and nuclear magnetic resonance spectroscopy (including 1H NMR, HH cosy, 13C NMR, DEPT, HSQC, HMBC) - (1-amino-8-azabicyclo [4.3.0] nonan-8-yl) -6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid.