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对卫生部北京生物制品研究所制备的脊髓灰质炎Ⅲ型液体疫苗（４５７－ⅢＰＦＩＺＥＲ－ＳｏＲｔ１），进行了人体接种反应和免疫效果观察。用加样枪口腔深部滴入疫苗后第６、８、１０、１２、１４天，有３０３％、６０６％、３０３％、１２１２％、９１０％接种儿出现全身弱反应，未见到中、强反应。未有发生皮疹、腹痛和腹泻者。免疫一个月后用中和试验查中和抗体，９６５５％（２８／２９）婴儿中和抗体升至１：１２８～１：１０２４，ＧＭＲＴ为４１２９０±３４７。结果表明，一次该疫苗免疫后Ⅲ型中和抗体的阳转率，和国内常规三价脊灰活疫苗３次免疫的一致。
The poliovirus type III liquid vaccine (457-ⅢPFIZER-SoRt1) prepared by the Beijing Institute of Biological Products, Ministry of Health, was used for human inoculation reaction and immune effect observation. At the 6th, 8th, 10th, 12th and 14th days after the vaccine was deeply injected into the mouth of the rats, 303%, 606%, 303%, 1212% and 910% Weak body reaction, did not see the strong reaction. No rashes, abdominal pain and diarrhea occurred. One month after the immunization, neutralizing antibodies were detected by neutralization test. 96.55% (28/29) infants neutralized antibodies increased to 1: 128-1: 1024 and GMRT was 412.9 ± 3.47. The results showed that the positive rate of neutralizing antibody of type III once immunized with the vaccine was consistent with the three immunizations of the conventional trivalent poliovirus in China.