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1.有效基团——肟含量:解(氯)磷定,可夺取磷酰化胆碱酯酶中的磷酰基,使胆碱酯酶解离出来,恢复共活性。解(氯)磷定有效基团——肟基(RCH=NOH)含量多少与其复活酶的能力有关。解磷定肟含量为51.9％,氯磷定为79.5％,经计算可知,1克氯磷定的药效约与1.5克解磷定相当。另外,氯磷定含氯离子更符合人体生理情况。 2.稳定性:解磷定水溶性小,溶液不稳定,久置能释出碘,释出碘后不宜应用。氯磷定水溶性高,使用方便;溶液性质稳定,不易分解破坏。 3.刺激性:解磷定刺激性大,静脉给药时药液漏到皮下可引起剧痛及周围组织麻木。氯磷定肌肉注
1. Effective groups - oxime content: solution (chlorine) phosphorus Ding, phosphoryl cholinesterase can capture phosphoryl, cholinesterase dissociation out, restore co-activity. Solution (chlorine) phosphorus effective group - oxime (RCH = NOH) content and its ability to revive the enzyme. Phosphorus determination of oxime content of 51.9%, chlorophyll is set to 79.5%, calculated to know, 1 g of chlorprorsine potency and about 1.5 grams of phosphate equivalent. In addition, chlorine chloride is more consistent with human physiological conditions. 2. Stability: Phosphoric solution of small water-soluble, solution instability, long set to release iodine, iodine release should not be applied. Chlorine phosphorus set water-soluble, easy to use; solution of stable quality, easy to break down. 3. Irritation: Phosphatidylinosidine irritation, intravenous drug leakage to the skin can cause acute pain and numbness around the organization. Chlorine phosphorus fixed muscle injection