论文部分内容阅读
本实验应用外淋巴灌流卡那霉素建立外毛细胞功能受损的动物模型，用微电极技术观察窒息后微音电位（CM）和负蜗内电位（－EP）的变化。发现在外淋巴灌流卡那霉素后CM振幅逐渐下降至一定程度后保持稳定，当窒息时，这部分CM随着EP下降而迅速消失，而单纯窒息动物CM并不完全消失。认为有一部分CM不仅与外毛细胞的存活有关，还与外毛细胞的功能有关。同时，我们还观察到外淋巴灌流卡那霉素后－EP的产生速度较快，认为－EP的产生也与外毛细胞的结构有关。
In this study, we established the animal model of impaired outer hair cells by using kanamycin induced by perilymph and observed the change of micro-tone potentials (CM) and negative-inspiratory potential (-EP) after asphyxiation using microelectrode technique. It was found that the amplitude of CM gradually decreased to some extent after perfused kanamycin. When asphyxiated, the part of CM disappeared rapidly with the decrease of EP, but the CM of pure asphyxia animal did not disappear completely. It is considered that some CMs are involved not only in the survival of outer hair cells but also in the function of outer hair cells. At the same time, we also observed that ecto-lymphocyte kanamycin -EP production rate is faster, that -EP production is also related to the structure of the outer hair cells.