老龄妇女(年龄≥70岁)卵巢癌的治疗模式

来源 :世界核心医学期刊文摘(妇产科学分册) | 被引量 : 0次 | 上传用户:WPF0731
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
. Elderly patients are less likely to receive surgery and platinum- based combination chemotherapy than younger patients. We evaluated multi-institutional management of ovarian cancer in the elderly. Methods. Charts of women with ovarian, primary peritoneal or fallopian tube cancer from 1/1996- 6/2004, age ≥ 70 years were reviewed. Age, stage, medical co-morbidities, surgery, chemotherapy, treatment modification, toxicity and survival were analyzed. Chi-square, logistic regression and survival analysis were used. Results. Of 131 patients, 90 were ages 70- 79 (group 1 = G1) and 41 were >80 years of age (group 2 = G2). Surgery was performed in 80 patients in G1; 25 patients in G2 (P = 0.001). Among patients who underwent surgery, optimal debulking and post-operative complications did not differ between groups. Ninety-five percent of patients received platinum-based therapy and 83% received combination platinum/paclitaxel in G1, compared to 90% and 41% , respectively, in G2 (P < 0.001). Of those receiving platinum therapy, 36% in G1 and 41% in G2 required dose reductions or termination of therapy. Forty percent of G1 and 50% of G2 required a delay of therapy; the majority occurring in patients receiving combination therapy. Hematological toxicity increased with use of combination therapy, but not with advancing age or Charlson score. Successful debulking surgery significantly impacted survival, and when controlling for this factor, age was not a significant variable. Conclusion. The extreme elderly had a decreased likelihood of receiving surgery and combination chemotherapy despite equivalent co-morbidities. In this analysis, optimal surgical cytoreduction had the greatest impact on survival. Elderly patients are less likely to receive surgery and platinum-based combination chemotherapy than younger patients. We evaluated multi-institutional management of ovarian cancer in the elderly. Methods. Charts of women with ovarian, primary peritoneal or fallopian tube cancer from 1/1996 Age, stage ≥ 70 years were reviewed. Age, stage, medical co-morbidities, surgery, chemotherapy, treatment, toxicity and survival were were. Analyzed by Chi-square, logistic regression and survival analysis were used. Patients were 90 years old 70-79 (group 1 = G1) and 41 were> 80 years of age (group 2 = G2). Surgery was performed in 80 patients in G1; 25 patients in G2 Ninety-five percent of patients received platinum-based therapy and 83% received platinum / paclitaxel in G1, compared to 90% and 41% respectively, respectively, in G2 (P <0.001). Of those receiving platinum therapy, 36% in G1 and 41% in G2 required dose reductions or termination of therapy. Forty percent of G1 and 50% of G2 required a delay of therapy; the majority occurring in patients receiving combination therapy. Hematological Toxicity Increased with use of combination therapy, but not with advancing age or Charlson score. Successful deblking surgery significantly impacted survival, and when controlling for this factor, age was not a significant variable. in this analysis, optimal surgical cytoreduction had the greatest impact on survival.
其他文献
目的研究虾青素对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)所致帕金森病小鼠模型是否具有神经保护作用以及机制。方法建立MPTP所致帕金森病小鼠模型,用虾青素预处理MPTP所致帕
Background: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC). However, it is import
未圆的编辑梦鹤鸣【咸阳】百梦而不成其真,然而,这梦总不可泯灭,那么还得始终如一地做下去。象经年已久的嗜烟者无法戒烟一样,我很难戒掉我的编辑之瘾。我发觉我已“病人膏肓”,很
8月27日,深圳广联赛讯有限公司在成都娇子音乐厅发布了驾宝盒子新品,发布会以“给汽车一颗互联网的智能心”为主题。而驾宝盒子的正式面世,也意味着广联赛讯打造的由DD BOX、
胃肝样腺癌(HAS)在临床上罕见[1].我科于2006年1月在为1例胃肝样腺癌伴肝转移患者施行胃大部切除胃十二指肠吻合根治术的同时行肝移植术.现报道如下。
中国传统文化,是一个由多元素结合起来,由简单到复杂的系统结构。在这个系统结构中,有哲学、文学、艺术、科学技术、经济、法律、政治、伦理、史学;还有心理结构、价值取向、
她们来自乡下,她们是人们常说的“小时工”。她们默默地用辛劳和汗水证明着自己存在的价值,尽管她们文化水平不高,劳动技能单一,但毫无疑问,越来越多的家庭已对她们产生了依
所谓“知己知彼,百战百胜”,各位男士有没有想过自己是否真的能够为性伴侣带来快乐?如果没有,就听听女士的心声,或许能从中汲取教训,重新建立良好的两性关系。 The so-calle
本月企业商品价格总水平较上月上涨0.7%,较上年同期上涨0.6%。从月环比指数看,去年下半年以来,企业商品价格保持了平缓回升趋势,今年年初受到季节性和“两节”因素影响,物价上涨势头较猛;从
“左手栏”是一项效果强大的技巧目的是让我们明白有哪些隐藏的假设主导了我们的谈话,阻碍了我们现实生活中的目标,并发展出更为有效的方式来讨论这些假设。借用这种方法,我