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目的:研究血清C反应蛋白水平、白细胞计数与急性脑梗死患者的梗死灶体积大小以及预后的关系。方法:检测70例急性脑梗死患者(CI组)、64例腔隙性脑梗死患者(LCI组)和80例健康人(对照组)的血浆CRP水平,并进行白细胞计数。在CI及LCI组人院当天和4周时进行临床神经功能缺损程度评分(NDS)评定以判断预后。结果:CI组血浆CRP水平高于LCI组及对照组(P<0.01),LCI组高于对照组(P<0.01);CI组白细胞计数高于LCI组及对照组(P<0.01),LCI组高于对照组(P<0.05);血浆CRP水平及白细胞计数正常组患者住院4周时显著进步和进步的比率明显高于血浆CRP水平及白细胞计数异常组(均P<0.01),而无变化和死亡的比率明显低于异常组(均P<0.01)。结论:ACI患者血浆CRP水平和白细胞计数均明显升高;脑梗死急性期血清CRP水平、白细胞计数可能与脑梗死患者梗死体积大小以及近期预后有密切的关系。
Objective: To study the relationship between serum C-reactive protein level, white blood cell count and infarct size and prognosis in patients with acute cerebral infarction. Methods: Plasma CRP levels were measured in 70 patients with acute cerebral infarction (CI group), 64 patients with lacunar infarction (LCI group) and 80 healthy people (control group), and the white blood cell count was measured. The clinical neurological deficit score (NDS) was assessed on the day of hospitalization and at 4 weeks in the CI and LCI groups to determine the prognosis. Results: The plasma CRP level in CI group was higher than that in LCI group and control group (P <0.01), LCI group was higher than that in control group (P <0.01), and the CI group was higher than LCI group and control group (P <0.01) (P <0.05). The plasma CRP levels and the patients with normal white blood cell count at 4 weeks after hospital admission were significantly higher than those in the control group (P <0.01) and no CRP levels and no abnormal white blood cell count The rates of change and death were significantly lower than those of the abnormal group (all P <0.01). Conclusion: The plasma levels of CRP and leukocyte counts in patients with ACI are significantly higher. Serum levels of CRP and leukocyte counts in acute stage of cerebral infarction may be closely related to infarct size and prognosis in patients with acute cerebral infarction.