复方新诺明对慢性尿路感染相当有效,在肾功能低下时本药的使用有两种不同看法。有作者认为肾功能低下者使用后可发生不可逆的肾功能恶化,复方新诺明用量应为常规剂量的1/2,且血清肌酐>mg/dl时应禁用;但亦有认为肾功能严重障碍者使用本药也没有问题。作者对14例尿路感染(主要为慢性肾小球肾炎和慢性肾盂肾炎)患者进行观察。其中男3例,女11例。年龄22～60(平均42)岁。用药前血清肌酐< Cotrimoxazole is very effective in treating chronic urinary tract infections. There are two different ways of using this medicine when renal dysfunction occurs. Some authors believe that the use of renal dysfunction may occur after irreversible deterioration of renal function, the amount of cotrimoxazole should be routine dose of 1/2, and serum creatinine> mg / dl should be disabled; but also considered a serious renal dysfunction Who use the drug is no problem. The authors observed 14 urinary tract infections (mainly chronic glomerulonephritis and chronic pyelonephritis) in patients. There were 3 males and 11 females. Age 22 ~ 60 (average 42) years old. Serum creatinine before treatment