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目的 描述成人社会获得性呼吸道流感病毒A(INFA)感染的规律和特点。方法 对 80 4例成人急性呼吸道感染和 15 6名同期平行健康对照采用间接酶联免疫吸附试验测定血清INFA特异性IgM抗体。 结果 ( 1) 80 4例病人中 ,17 6%INFA -IgM抗体阳性 ,明显高于对照组 (P <0 0 1) ;3 1 3 %肺心病、2 3 3 %支气管炎、2 2 2 %支气管扩张、2 1 6%败血症、19 2 %哮喘加重、16 6%社会获得性肺炎、13 1%慢性阻塞性肺疾病 (COPD)急性加重、62 5 %急性心肌炎INFA -IgM阳性 ,分别非常显著高于对照组 (P均小于 0 0 1) ;15 0 %慢性肾功能不全 ,显著高于对照组 (P <0 0 5 )。 ( 2 ) 13 3例INFA -IgM抗体阳性中 ,48 1%有基础疾病 ;<3 6岁组 ,无基础疾病 ;3 6～ 65岁组 ,3 5 3～ 41 4%有基础疾病 ;66～ 75岁组 ,48 5 %有基础疾病 ;76～ 85岁组 ,68 8%有基础疾病 ;86岁以上组 ,10 0 %有基础疾病。 ( 3 ) 3年 2个月中 ,INFA -IgM抗体阳性结果主要集中在秋末、冬季和初春 ,其它季节散发。结论 ( 1)INFA是成人社会获得性呼吸道感染中重要的致病原 ;( 2 )部分气流限制性疾病、慢性左心功能不全急性加重与INFA感染有关 ;( 3 )INFA感染与基础疾病有关 ;( 4)INFA感染在秋冬春季高发
Objective To describe the rules and characteristics of adult social acquired respiratory influenza virus A (INFA) infection. Methods Serum INFA specific IgM antibody was measured by indirect enzyme-linked immunosorbent assay in 80 4 adult acute respiratory infections and 15 6 parallel healthy controls. Results (1) Of the 804 patients, 17 6% of INFA-IgM antibodies were significantly higher than those of the control group (P <0.01); 33% of patients with pulmonary heart disease, 23.3% of patients with bronchitis, 22.2% Bronchiectasis, 26% sepsis, 19.2% asthma exacerbations, 16.6% social-acquired pneumonia, 13.1% acute exacerbations of COPD, and 62.5% positive for INFA-IgM in acute myocarditis, respectively Higher than the control group (P <0.01); 15 0% chronic renal insufficiency was significantly higher than the control group (P <0 05). (2) In 13 3 cases of positive INFA-IgM antibodies, 48.1% had underlying diseases; <36 years old, no underlying diseases; 36 to 65 years old; 35 to 41.4% had underlying diseases; 75 years old group, 48.5% had basic disease; 76-85 years old group, 68.8% had basic disease; 86 years old group, 10% had underlying disease. (3) In 3 years and 2 months, the positive results of INFA-IgM antibody mainly concentrated in autumn, winter and early spring, and were distributed in other seasons. CONCLUSIONS: (1) INFA is an important causative agent in adult acquired respiratory tract infections (SARS). (2) Some airflow limitation diseases and acute exacerbation of chronic left ventricular dysfunction are associated with INFA infection. (3) INFA infection is associated with underlying diseases. (4) INFA infection in the spring and autumn high incidence