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目的：探讨黄芪当归合剂（合剂）调节脂代谢紊乱的可能机理。方法：在肾病综合征（ＮＳ）高脂血症及高胆固醇血症大鼠，观察合剂对血清白蛋白、血脂及脂质降解的两个关键酶脂蛋白脂酶（ＬＰＬ）和卵磷脂胆固醇酰基转移酶（ＬＣＡＴ）活性的影响。结果：ＮＳ大鼠出现明显低白蛋白、高脂血症，同时ＬＰＬ活性降低，ＬＣＡＴ活性相对不足；在ＮＳ大鼠应用合剂治疗后，不仅血清白蛋白明显升高、血脂明显下降，ＬＰＬ及ＬＣＡＴ活性亦明显增加；高胆固醇血症时ＬＰＬ及ＬＣＡＴ活性无明显改变，合剂对其活性亦无影响。结论：ＮＳ大鼠ＬＰＬ活性降低，ＬＣＡＴ活性相对不足是其高脂血症发生机理之一。合剂通过增加ＬＰＬ和ＬＣＡＴ活性，促进循环中含载脂蛋白Ｂ（ａｐｏＢ）、富甘油三酯及富胆固醇脂蛋白的降解起调脂作用
Objective: To investigate the possible mechanism of Huangqi Angelica mixture (mixture) in regulating lipid metabolism disorders. METHODS: In the nephrotic syndrome (NS) hyperlipidemia and hypercholesterolemia rats, the two key enzymes lipoprotein lipase (LPL) and lecithin cholesterol acyl group were observed for the degradation of serum albumin, lipids, and lipids. The effect of transferase (LCAT) activity. RESULTS: NS rats showed marked hypoalbuminemia, hyperlipidemia, LPL activity, and LCAT activity were relatively insufficient. After treatment with NS rats, serum albumin was significantly elevated, blood lipids were significantly decreased, and LPL and LCAT were significantly decreased. Activity also significantly increased; LPL and LCAT activity did not change significantly in hypercholesterolemia, and the mixture had no effect on its activity. Conclusion: The activity of LPL in NS rats is decreased. The relative deficiency of LCAT activity is one of the mechanisms of hyperlipidemia. The mixture enhances lipid metabolism by increasing LPL and LCAT activity and promoting the degradation of apolipoprotein B (apoB), triglyceride-rich and cholesterol-rich lipoproteins in circulation.