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目的了解辛伐他汀对高胆固醇血症的治疗效果。方法选择总胆固醇≥6.0mmol/L的患者,给予辛伐他汀剂量20mg,每日1次,晚间顿服、连续服用8周后测定治疗前后总胆固醇的水平。结果治疗前后胆固醇[分别为(6.85±0.21)mmol/L和(5.52±0.32)mmol/L],与低密度脂蛋白胆固醇[分别为(4.02±0.81)mmol/L和(3.25±0.67)mmol/L]水平比较,差异有统计学意义(P<0.01)。结论辛伐他汀服用方便,少见不良反应,是治疗高胆固醇血症的理想药物。
Objective To understand the effect of simvastatin on hypercholesterolemia. Methods Patients with total cholesterol≥6.0mmol / L were given simvastatin 20mg once daily and evening before serving for 8 weeks. The levels of total cholesterol before and after treatment were measured. Results Before and after treatment, the levels of cholesterol ([(6.85 ± 0.21) mmol / L and (5.52 ± 0.32) mmol / L] and LDL cholesterol [4.02 ± 0.81 mmol / L and 3.25 ± 0.67 mmol / / L] levels, the difference was statistically significant (P <0.01). Conclusions Simvastatin is an ideal drug for the treatment of hypercholesterolemia because of its convenient administration and rare adverse reactions.