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目的探讨短期丰富生存环境干预对老年雄性大鼠大脑白质及白质内有髓神经纤维的影响。方法将20只24月龄雄性SD大鼠分别在丰富生存环境条件和普通标准环境下饲养4个月后,从每组随机抽取4只大鼠,用透射电子显微镜和体视学方法比较两组大鼠大脑白质及白质内有髓神经纤维的改变。结果丰富生存环境组大鼠的白质总体积,白质内有髓神经纤维总长度和总体积,有髓神经纤维轴突总体积分别较标准对照组显著增大,但有髓神经纤维平均内径、外径、髓鞘总体积、髓鞘平均厚度、髓鞘平均内、外周长、有髓神经纤维断面面积、髓鞘断面面积及轴突断面面积较对照组均无明显差异。结论短期丰富生存环境干预对24月龄雄性大鼠的大脑白质和白质内有髓神经纤维均有明显的影响。提示短期丰富生存环境可能促使老年雄性大鼠白质内已经发生脱髓鞘改变的有髓神经纤维出现髓鞘再生。
Objective To investigate the effects of short-term abundant living environment intervention on myelinated nerve fibers in white matter and white matter of aged male rats. Methods Twenty twenty-four-month-old male Sprague-Dawley rats were fed for 4 months under rich living conditions and normal standard conditions. Four rats were randomly selected from each group. Transmission electron microscopy and stereological methods were used to compare the two groups Changes of white matter and white matter myelinated nerve fibers in rat brain. Results The total volume of white matter, the total length of myelinated nerve fibers and the total volume of myelinated nerve fibers and the total volume of myelinated nerve fibers in the enriched environment group were significantly higher than those of the normal control group, respectively. However, the mean diameter of myelinated nerve fibers, There was no significant difference in diameter, total volume of myelin, average thickness of myelin sheath, average internal and external myelin sheath length, area of myelinated nerve fibers, area of myelin sheaths and axonal cross-section. Conclusion The intervention of short-term abundant living environment can significantly affect the white matter and white matter myelinated nerve fibers in 24-month-old male rats. It suggests that short-term abundant living environment may promote remyelination of myelinated nerve fibers in the white matter of aged male rats that have been demyelinated.